Relevant publications by study team members and others

High throughput screening and chemical policy

Collins FS, Gray GM, Bucher JR. 2008. Toxicology. Transforming environmental health protection. Science, 319(5865):906-907. Article

North M, Vulpe CD. 2010. Functional toxicogenomics: mechanism-centered toxicology. International Journal of Molecular Sciences, 11(12):4796-4813. Article

Committee on Toxicity Testing and Assessment of Environmental Agents, National Research Council. Toxicity testing in the 21st century:a vision and a strategy. 2007. Article

Schwarzman MR, Wilson MP. 2009. Science and regulation. New science for chemicals policy. Science, 326(5956):1065-1066. Article

Breast cancer pathways and model systems

Rudel, R.A., K. R. Attfield, J. Schifano, J.G. Brody. 2007. Chemicals causing mammary gland tumors in animals signal new directions for epidemiology, chemicals testing, and risk assessment for breast cancer prevention. Cancer, 109 (S12): 2635-2666. Article , Summary

Rudel, R.A, S.E. Fenton, J.M. Ackerman, S.Y. Euling, S.L. Makris. 2011. Environmental Exposures and Mammary Gland Development: State of the Science, Public Health Implications, and Research Recommendations. Environmental Health Perspectives, 119(8). doi:10.1289/ehp.1002864 Article , Press Release

Meg Schwartzman and Sarah Janssen. 2010. Pathways to Breast Cancer. Article

Leitman DC, Paruthiyil S, Yuan C, Herber CB, Olshansky M, Tagliaferri M, Cohen I, Speed TP. 2012. Tissue-specific regulation of genes by estrogen receptors. Seminars in Reproductive Medicine, 30(1):14-22. Abstract

Leitman DC, Paruthiyil S, Vivar OI, Saunier EF, Herber CB, Cohen I, Tagliaferri M, Speed TP. 2010. Regulation of specific target genes and biological responses by estrogen receptor subtype agonists. Current Opinion in Pharmacology 10(6): 629-636. Article

Cvoro A, Yuan C, Paruthiyil S, Miller OH, Yamamoto KR, Leitman DC. 2011. Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes. Journal of Immunology, 186(7):4354-4360. Article

Wong C, Chen S. 2012. The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance. Journal of Steroid Biochemistry and Molecular Biology, 131(3-5):83-92. Abstract

Chen S. 2011. An "omics" approach to determine the mechanisms of acquired aromatase inhibitor resistance. OMICS, 15(6):347-352. Article

Nguyen-Ngoc KV, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, Ewald AJ. 2012. ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proceedings of the National Academy of Sciences of the United States of America 109(39): E2595-2604. Article

Pirone JR, D'Arcy M, Stewart DA, Hines WC, Johnson M, Gould MN, Yaswen P, Jerry DJ, Smith Schneider S, Troester MA. 2012. Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer. Cancer Epidemiology Biomarkers and Prevention 21(10): 1735-1744. Article

Chemical Screening Program

Kavlock R, Chandler K, Houck K, Hunter S, Judson R, Kleinstreuer N, Knudsen T, Martin M, Padilla S, Reif D et al. 2012. Update on EPA's ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management. Chemical Research in Toxicology. Abstract

Tice RR, Austin CP, Kavlock RJ, Bucher JR. 2013. Improving the human hazard characterization of chemicals: a Tox21 update. Environmental Health Perspectives 121(7): 756-765. Article

Kleinstreuer NC, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Paul KB, Reif DM, Crofton KM, Hamilton K, Hunter R, Shah I, Judson RS. 2012. In vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. Toxicological Sciences. Article

Knight AW, Little S, Houck K, Dix D, Judson R, Richard A, McCarroll N, Akerman G, Yang C, Birrell L, Walmsley RM. 2009. Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals.Regulatory Toxicology and Pharmacology 55(2): 188-199. Abstract

Sipes NS, Martin MT, Kothiya P, Reif DM, Judson RS, Richard AM, Houck KA, Dix DJ, Kavlock RJ, Knudsen TB. 2013. Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays. Chemical Research in Toxicology. Article

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