Alexandre Borrel, PhD
Dr. Alexandre Borrel is a Research Scientist with expertise in bioinformatics and chemistry. His research centers on the use of chemical structures to establish links between chemicals and toxicity. With expertise in big data and artificial intelligence, he has developed numerous tools for characterizing and visualizing the chemical space and bioactivity of different compounds in order to develop new approaches for predictive toxicity.
His current work is focused on analyzing gene expression changes in breast cancer cells and breast organoids in response to chemical treatments in order to discern chemically-induced biological effects, and to adapt the technology for chemical safety evaluation. He is also developing approaches for using chemical structure and bioactivity to predict toxicity and carcinogenicity, and to identify closely-related chemicals that may share toxicity characteristics. One of the goals is to apply these approaches to streamline risk evaluation for per- and polyfluoroalkyl substances (PFAS) and organohalogen flame retardants.
Prior to joining Silent Spring in 2020, Dr. Borrel worked as a Postdoctoral Fellow at the National Institute of Environmental Health Sciences (NIEHS), where he developed computational pipelines to analyze high-throughput screening data as well as new methods for visualizing assay outputs in relation to chemical structures. He was part of the Key Characteristics group that defined properties of chemicals and other agents that confer potential hazard based on properties of known human carcinogens.
Dr. Borrel earned a joint PhD in Bioinformatics and Chemistry from the University of Paris in France and the University of Helsinki in Finland where he developed new methods to statistically characterize the interaction between a chemical and a protein in an organism.
Publications & Presentations
Rudel, R.A., B. Cardona, A. Borrel, J.E. Kay. 2022. Response to “Comment on ‘Application of an in Vitro Assay to Identify Chemicals That Increase Estradiol and Progesterone Synthesis and Are Potential Breast Cancer Risk Factors’”. Environmental Health Perspectives. https://doi.org/10.1289/EHP11400